Detalhe da pesquisa
1.
AMPK mediates energetic stress-induced liver GDF15.
FASEB J
; 35(1): e21218, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33337559
2.
Structure activity relationships leading to the identification of the indirect activator of AMPK, R419.
Bioorg Med Chem
; 71: 116951, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35973281
3.
Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J Biol Chem
; 294(3): 953-967, 2019 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30478170
4.
Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus.
Bioorg Med Chem Lett
; 27(11): 2617-2621, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28408219
5.
Developing structure-activity relationships from an HTS hit for inhibition of the Cks1-Skp2 protein-protein interaction.
Bioorg Med Chem Lett
; 25(22): 5199-202, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26463131
6.
Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.
Am J Physiol Heart Circ Physiol
; 306(8): H1128-45, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24561866
7.
Enantioselective synthesis of cis-3-fluoropiperidin-4-ol, a building block for medicinal chemistry.
J Org Chem
; 78(17): 8892-7, 2013 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-23957501
8.
Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators.
J Med Chem
; 66(24): 17086-17104, 2023 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38079537
9.
Tuning the Reactivity of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Optimal in Vivo Efficacy.
ACS Med Chem Lett
; 14(12): 1700-1706, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116420
10.
The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series.
Bioorg Med Chem Lett
; 21(12): 3712-4, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21570844
11.
Brain Permeable AMP-Activated Protein Kinase Activator R481 Raises Glycaemia by Autonomic Nervous System Activation and Amplifies the Counterregulatory Response to Hypoglycaemia in Rats.
Front Endocrinol (Lausanne)
; 12: 697445, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34975743
12.
9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety.
Bioorg Med Chem
; 18(21): 7651-8, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20869254
13.
The structure activity relationship of discodermolide analogues.
Mini Rev Med Chem
; 8(3): 276-84, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18336347
14.
Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide.
Org Lett
; 7(2): 315-8, 2005 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15646986
15.
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide.
Org Lett
; 7(2): 311-4, 2005 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15646985
16.
15-amido erythromycins: synthesis and in vitro activity of a new class of macrolide antibiotics.
J Antibiot (Tokyo)
; 58(3): 167-77, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15895524
17.
Global metabolite profiling of mice with high-fat diet-induced obesity chronically treated with AMPK activators R118 or metformin reveals tissue-selective alterations in metabolic pathways.
BMC Res Notes
; 7: 674, 2014 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25252968
18.
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.
PLoS One
; 8(12): e81870, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24339975
19.
Structure-activity relationships of 9-substituted-9-dihydroerythromycin-based motilin agonists: optimizing for potency and safety.
J Med Chem
; 52(21): 6851-9, 2009 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19821563
20.
Investigating amine derivatives of ambruticin VS-5 and VS-4.
ChemMedChem
; 3(6): 963-9, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18307190